That's quite interesting...what error do you get?
Also, did you try using the "Write Sound Files" option in the Soundboard category instead of the"Download To Saber" button? Sometimes the button doesn't work accurately, depending on the computer configurations...
Normally, it shouldn't make a difference if you use a saved profile or if you configure it via Drag&Drop and write it directly to the board
Also, make sure you have the Launcher both installed and run as administrator. It can make a huge difference if you don't install and run it as admin!